ABSTRACT
Abstract Susceptibility to cancer ensues in individuals carrying malfunctioning DNA repair mechanisms. The impact of Single Nucleotide Polymorphisms (SNPs) in key DNA repair mechanisms on risk for prostate cancer was investigated in this case-control study. Samples consisted of 110 patients with confirmed prostate cancer and 200 unaffected men, from Rio de Janeiro, Brazil. XPD/Lys751Gln (rs13181), APEX1/Asp148Glu (rs1130409), and RAD51/G135C (rs1801320) SNPs were analyzed by PCR-RFLP. Allelic and genotypic frequencies were calculated and compared by Chi-Square test. The association between SNPs and clinical/epidemiological data was considered significant by Odds Ratio analysis, with IC95% and a p-value≤0.05. Only the XPD/Lys751Gln SNP significantly increased susceptibility to disease in southeastern Brazilian men, with p≤0.001 [OR=2.36 (1.46-3.84)], with no association with APEX1 or RAD51 SNPs. Combined XPD+RAD51 SNPs were highly associated with the disease, p≤0.005 [OR=3.40 (1.32-9.20)]. A Chi-Square significant association between XPD/Lys751Gln and Gleason score was also observed (OR=9.31; IC95%=1.19-428.0; p=0.022). Epidemiological inquiries revealed that exposure to pesticides significantly impacted the risk for prostate cancer in this population. DNA repair dysfunctions seem to prevail among workers exposed to chemical byproducts to cancer in this specific tissue. Non-invasive genotyping SNPs may help assessment of prostate cancer risk in environmentally exposed populations.
ABSTRACT
Este ensaio clinico prospectivo consistiu na observacao de 30 pacientes portadores de infeccao urinaria aguda, de instalacao recente, na maioria dos casos cistites e uretrites. O criterio de inclusao foi baseado principalmente no quadro sintomatologico, independentemente do resultado das uroculturas. Pacientes de ambos os sexos foram tratados ambulatorialmente com acido pipemidico, um derivado quinolonico em dose unica de 1.600 mg por via oral. Obtivemos a remissao dos sintomas na maioria dos casos tratados, isto e, em 27 pacientes (90%), independentemente do resultado da cultura pre ou pos-medicacao. Concluimos que o tratamento com o acido pipemicico e eficaz nos casos agudos incipientes de infeccao urinaria
Subject(s)
Adolescent , Adult , Middle Aged , Humans , Male , Female , Nicotinic Acids , Urinary Tract InfectionsABSTRACT
Os autores mostram a dificuldade de diagnóstico do angiomiolipoma renal em dois casos, nos quais o tumor näo manifesta quadro clínico próprio, mas adota a sintomatologia geral de qualquer massa expansiva renal. É ressaltada também a associaçäo deste tumor com a esclerose tuberosa de Bourneville
Subject(s)
Middle Aged , Humans , Female , Kidney Neoplasms/complications , Kidney Neoplasms/diagnosis , Lipoma/complications , Lipoma/diagnosis , Tuberous Sclerosis/complications , BrazilABSTRACT
Os autores abordam aspectos gerais da patologia, analisando os casos reportados segundo as observaçöes clínicas, anatomopatológicas, laboratoriais e radiológicas referentes a esta entidade. Säo apresentados três casos, ressaltando os autores a dificuldade de diagnóstico, devido à inespecificidade dos exames clínicos, laboratoriais e radiológicos